The Influence of Regular Physical Exercise on the Advanced Glycated End Products

Advanced Glycated End-products (AGEs) are heterogeneous glycated metabolites of protein, lipid, or nucleic acid. They are products of a chain of chemical reactions endogenously or diet and tobacco smoking exogenously. They exert significant pathological effects on many body tissues, leading to chronic disease complications such as diabetes, cardiovascular diseases, Alzheimer’s disease, etc. This narrative review shows that there are no agreed management options to reduce the AGEs level. However, regular Physical Exercise (PE) has a positive impact on the serum AGEs level through multiple additive metabolic effects associated with weight management, reduction in insulin sensitivity, decrease in receptors of AGEs, oxidative stress, and an overall improvement in the AGEs hemostasis. Evidence supports the synergistic effect of changing lifestyle, including regular PE on the progression of AGEs. Nevertheless, the literature needs further clinical evidence to address the required PE prescription that would be sufficient to reduce AGEs levels.

Keywords: Advanced glycated end-products; Physical exercise; Chronic disease; Diabetes mellitus; Aging

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