Role of “NAFLAN” Immune (Nasal/ Oral) Spray in Prevention of Respiratory Virus Infections (Including COVID 19) in Indian Volunteers: The Preliminary R

Background & Objectives: The Immune-modulating Nutritional Supplements based on Grapeseeds rich n Sterols and Vitamins can be useful in the Management of Respiratory Viral infections including COVID 19, but studies revealing their combined effects are lacking in the literature. Therefore the German manufactured Oro-Nasal Immune spray (NAFLAN- A Nutritional Supplements Product) based on a combination of Plant Sterols & Vitamin, B, D, E needs urgent exploration in the context of the Prevailing COVID 19 Pandemic across the world including India.

Methods: This clinical trial was done on 40 healthy Volunteers, as part of a Phase 1 trial Project of Pure Derm GmBH, Germany for its evaluation in the Management of Respiratory Infections including COVID 19. The volunteers were selected from an NGO Hosp????tal and th????s trial was enrolled at CTRI ICMR India and conducted according to WHO, PATH & CONSORT guidelines. The trial was done from 15th March 2021- 15th June 2021 in wh????ch th????s Immune spray was used for 1 month (1st May 2021- 31st May). This Clinical trial included all types of COVID 19 including the Indian Mutation Delta Variant.

Results: Symptoms such as Cough and Diarrhea were reduced significantly after the use of Immune( Nafl a Spray) [χ2 =9.25 (Yates Correct????on), P <0.05, RR Adjusted=1.8, 95% C.I=1.5-2.1], but no effect on high fever, headache, and Common cold were seen.

Interpretation & Conclusions: Nafalan Spray can be useful in the Prevention of Cough in Respiratory Infections (possibly also COVID 19). However Large scale Multicentric trial is however advocated by authors before reaching a more definite conclusion regarding the role of Nafalan Spray in the Prevention of COVID 19 Infection.

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