Editorial Note
Atherosclerotic cardiovascular disease (ASCVD) is a leading global health concern, signi????icantly contributing to acute cardiovascular events such as myocardial infarction and ischemic stroke. Research consistently links elevated levels of low-density lipoprotein cholesterol (LDL-C) to ASCVD. Preventive measures and early interventions can mitigate the disease’s progression [1]. Yet, despite advancements in medical treatments and the known bene????its of lifestyle modi????ications like exercise and reduced saturated fat intake, ASCVD mortality rates continue to rise globally. Modern medical practices often fall short of eradicating ASCVD risk, emphasizing the need for more precise and proactive approaches. Delayed or inappropriate care ampli????ies the risk and complications of ASCVD, urging the necessity for improved preventive guidelines and risk assessment tools. Elevated Low-density lipoprotein cholesterol (LDL-C) levels play a pivotal role in the progression of Atherosclerotic cardiovascular disease (ASCVD). Studies reveal a direct relationship between LDL-C levels and ASCVD risk, necessitating guidelines for LDL-C reduction. Despite the guidelines recommending statins as ????irst-line therapy for lowering LDL-C [2], many patients fail to meet the thresholds. These guidelines face challenges in being upto- date, personalized, and comprehensible. Medical practitioners often delay adopting new therapeutic approaches, resulting in many patients with dyslipidemia going untreated [3, 4]. Moreover, within six months, half of the high-risk patients discontinue statin therapy prematurely, increasing their ASCVD risk. Early and accurate assessment tools for atherosclerosis are underused. The essence of medicine involves tailoring scienti????ic evidence to individuals. The understanding of atherosclerosis at molecular and lifestyle levels has expanded. National and international guidelines recommend lipid-lowering drugs based on cardiovascular risk calculations, with variations in prediction tools and thresholds.
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