ISSN: Coming soon...

MSD Global Journal of Cancer Therapy, Immunotherapy and Radiology

Case Report       Open Access      Peer-Reviewed

A Rare Presentation of Metastatic Breast Carcinoma to the Thyroid Three Years after Mastectomy: A Case Report

Mohammed Al Duhileb, Breast and Endocrine Oncology Surgeon, King Fahad Specialist Hospital-Dammam, Saudi Arabia; Tel: +966595909590, Email: duhailebm@hotmail.com

Abstract

Introduction: Breast cancer is the most common cancer in women. Yet, metastasis to the thyroid is a rare occurrence. Here we present the case of a patient with breast cancer metastasis to the thyroid gland to discuss the management of such presentations compared to the current literature. We also present this case to add to the existing literature and aid in the expansion and better understanding of rare incidences as such.

Presentation of Case: A 38-year-old female with no chronic medical illnesses was diagnosed with. invasive ductal carcinoma of the right breast T3N0M0 in 2017. Chemotherapy consists of eight cycles of neoadjuvant chemotherapy followed by a simple mastectomy, sentinel lymph node biopsy, and adjuvant radiation to the chest wall. The patient has been on hormonal therapy since diagnosis. In 2020, the patient presented with a left neck mass and underwent a total thyroidectomy. Pathological analysis of the specimen confirmed the presence of poorly differentiated cells consistent with mammary ductal cells while the right thyroid lobe demonstrated features of papillary thyroid carcinoma.

Conclusion: Intrathyroidal metastasis of extrathyroidal cancers is rare but should be considered when patients are present with a history of cancer. Thyroidectomies in isolated secondary thyroid cancers have been shown to prolong the disease-free period but are not a definitive cure.

Keywords: Case Report, Breast Cancer, Metastases, Thyroid Cancer.

Introduction

Breast cancer is the most common cancer in women. It frequently metastasizes to the lungs, bone, liver, and brain. Yet, metastasis to the thyroid is a rare occurrence with an incidence rate of 0.02-1.4% [1, 2]. As a result, the literature is scarce and there is no proven way on the best management plan. Here we present the case of a patient with breast cancer metastasis to the thyroid gland three years after the completion of her treatment of breast carcinoma followed by a discussion of the management of secondary thyroid cancer compared to the current literature.

Presentation of Case

This is a case of a 38-year-old Saudi female who presented to the breast clinic with a right breast mass in 2017 for one year with no other symptoms and no risk factors for breast cancer. Her past medical and surgical history were not signi????icant. Her medication history, psychosocial history, and family history were unremarkable....... 

 

References

1. Irvin W, Muss HB, Mayer DK (2011) Symptom management in metastatic breast cancer. Oncologist 16:1203-1214. Link: https://bit.ly/4bGA0mc

2. Nixon IJ, Whitcher M, Glick J, Palmer FL, Shaha AR, et al. (2011) Surgical management of metastases to the thyroid gland. Ann Surg Oncol 18: 800-804. Link: https://bit.ly/3OOE22b

3. Zhou L, Chen L, Xu D, Shao Q, Guo Z, et al. (2017) Breast cancer metastasis to thyroid: a retrospective analysis. Afr Health Sci 17: 1035-1043. Link: https://bit.ly/3wkC97a

4. Surov A, Machens A, Holzhausen HJ, Spielmann RP, Dralle H (2016) Radiological features of metastases to the thyroid. Acta Radiol 57 :444-450. Link: https://bit.ly/49dwnCF

5. Chung AY, Tran TB, Brumund KT, Weisman RA, Bouvet M (2012) Metastases to the thyroid: a review of the literature from the last decade. Thyroid 22: 258-268. Link: https://bit.ly/3UAhdmG

6. Hegerova L, Griebeler ML, Reynolds JP, Henry MR, Gharib H (2015) Metastasis to the thyroid gland: report of a large series from the Mayo Clinic. Am J Clin Oncol 38: 338-342. Link: https://bit.ly/48iU6QN

7. Aron M, Kapila K, Verma K (2006) Role of fi ne-needle aspiration cytology in the diagnosis of secondary tumors of the thyroid--twenty years’ experience. Diagn Cytopathol 34: 240-245. Link: https://bit.ly/3OJrlWw

8. Mirallié E, Rigaud J, Mathonnet M, Gibelin H, Regenet N, et al. (2005) Management and prognosis of metastases to the thyroid gland. J Am Coll Surg 200: 203-207. Link: https://bit.ly/3UHB1ob

9. McCabe DP, Farrar WB, Petkov TM, Finkelmeier W, O’Dwyer P, et al. (1985) Clinical and pathologic correlations in disease metastatic to the thyroid gland. Am J Surg 150: 519-523. Link: https://bit.ly/42JCBYO

10. Calzolari F, Sartori PV, Talarico C, Parmeggiani D, Beretta E, et al. (2008) Surgical treatment of intrathyroid metastases: preliminary results of a multicentric study. Anticancer Res 28: 2885-2888. Link: https://bit.ly/3SJoL3Z

11. Cicho? S, Anielski R, Konturek A, Barczy?ski M, Cicho? W (2006) Metastases to the thyroid gland: seventeen cases operated on in a single clinical center. Langenbecks Arch Surg 391: 581-587. Link: https://bit.ly/3HZrUrd

12. Papi G, Fadda G, Corsello SM, Corrado S, Rossi ED, et al. (2007) Metastases to the thyroid gland: prevalence, clinicopathological aspects and prognosis: a 10-year experience. Clin Endocrinol (Oxf) 66: 565-571. Link: https://bit.ly/3OLhBeb

Coming Soon...